Alpha-2 adrenergic agonists
نویسندگان
چکیده
منابع مشابه
Withdrawal reactions following cessation of central alpha-adrenergic receptor agonists.
Interruption of long-term treatment with alpha 2-adrenergic receptor agonists may be associated with reversal of their hemodynamic effects, clinical and biochemical evidence of increased peripheral sympathetic activity, and behavioral responses similar to those seen after narcotic or alcohol withdrawal. Reactions are most commonly observed after short-acting imidazoline drugs such as clonidine ...
متن کاملAlpha-2 adrenergic receptor agonists are neuroprotective in experimental models of glaucoma.
PURPOSE The glaucomas are characterized by chronic progressive ganglion cell loss over many years. A drug with neuroprotective activity should increase the resistance of retinal ganglion cells (RGC) to chronic stress or injury and therefore enhance survival. Brimonidine is a highly selective and potent alpha-2 adrenergic receptor agonist, which lowers intra-ocu-lar pressure (IOP) and is neuropr...
متن کاملAlpha 2 adrenergic agonists stimulate Na+-H+ antiport activity in the rabbit renal proximal tubule.
The role of adrenergic agents in augmenting proximal tubular salt and water flux, was studied in a preparation of freshly isolated rabbit renal proximal tubular cells in suspension. Norepinephrine (NE, 10(-5) M) increased sodium influx (JNa) 60 +/- 5% above control value. The alpha adrenergic antagonist, phentolamine (10(-5) M), inhibited the NE-induced enhanced JNa by 90 +/- 2%, while the beta...
متن کاملEffects of alpha(2)-adrenergic agonists on lipopolysaccharide-induced aqueous flare elevation in pigmented rabbits.
PURPOSE To evaluate the effects of the alpha(2)-adrenergic agonists (clonidine, apraclonidine, and guanfacine) on lipopolysaccharide (LPS)-induced aqueous flare elevation in pigmented rabbits. METHODS Anterior uveitis was induced with an intravenous injection of LPS (0.5 microg/kg) in an ear vein. The reproducibility of experimental uveitis induced by LPS (0.5 microg/kg) was also determined. ...
متن کاملVasoconstrictive versus vasodilatory effects of alpha-2 adrenergic agonists on the spinal microcirculation.
To the Editor:—I read with interest the study about the effect of a-2 adrenergic agonists on the spinal pial microcirculation in dogs. Using an in vivo technique, the authors observed a significant constriction of both pial arterioles and venules after topical application of clonidine or dexmedetomidine. They suggested that a-2 agonists might be superior to epinephrine or phenylephrine as local...
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ژورنال
عنوان ژورنال: Canadian Journal of Anaesthesia
سال: 1997
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03022261